By Ragu Ramanathan
Evolving function of mass spectrometry in drug discovery and improvement / Dil M. Ramanathan and Richard M. LeLacheur -- Quantitative bioanalysis in drug discovery and improvement: rules and functions / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen -- Quadrupole, triple-quadrupole, and hybrid linear ion seize mass spectrometers in metabolite research / Elliott B. Jones -- functions of quadrupole time-of-flight mass spectrometry in reactive metabolite screening / Jose M. Castro-Perez -- altering position of FTMS in drug metabolism / Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders -- High-resolution LC-MS dependent mass disorder filter out technique: easy suggestion and alertness in metabolite detection / Haiying Zhang ... [et al.]., purposes of high-sensitivity mass spectrometry and radioactivity detection innovations in drug metabolism stories / Wing W. Lam ... [et al.] -- on-line electrochemical-LC-MS options for profiling and characterizing metabolites and degradants / Paul H. Gamache ... [et al.] -- LC-MS equipment with hydrogen/deuterium alternate for identity of hydroxylamine, n-oxide, and hydroxylated analogs of desloratadine / Natalia A. Penner ... [et al.] -- Turbulent-flow LC-MS: purposes for accelerating pharmacokinetic profiling and metabolite identity / Joseph L. Herman and Joseph M. Di Bussolo -- Desorption ionization options for quantitative research of drug molecules / Jason S. Gobey, John Janiszewski, and Mark J. Cole -- MALDI imaging mass spectrometry for direct tissue research of prescribed drugs / Yunsheng Hsieh and Walter A. Korfmacher
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Evolving function of mass spectrometry in drug discovery and improvement / Dil M. Ramanathan and Richard M. LeLacheur -- Quantitative bioanalysis in drug discovery and improvement: ideas and purposes / Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen -- Quadrupole, triple-quadrupole, and hybrid linear ion capture mass spectrometers in metabolite research / Elliott B.
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10. LC– MS spectra of mometasone in the presence of PPG interferences obtained under unit- and enhanced-resolution settings showing the minimum loss in ion transmission under enhanced-resolution settings. 11. LC– MS/MS chromatograms of desloratadine (SCH 34117) (fortified into plasma) obtained under unit- and enhanced-mass-resolution conditions. 12. Calibration curves for loratadine (SCH 29851) and desloratadine (SCH 34117) obtained under unit- and enhanced-resolution conditions. 999). The lower correlation coefficients under enhanced-resolution conditions might have resulted from a slight mass window shift during the long overnight 17-h run.
21b) due to the N-oxide metabolite (m/z 506) undergoing fragmentation in the ESI source. In-source fragmentation of the N-oxide (compound B) resulted in the formation of m/z 488 ions through loss of an oxygen atom, which in turn contributed to Compound A transition of 488 ! 401. The on-line FAIMS set-up allowed the metabolite interference to be removed before the entrance to the mass spectrometer. Hatsis et al. (2007) showed that FAIMS can be used to increase quantitation throughput by eliminating chromatography altogether.
To avoid analyzing the samples for the second time and to improve upon King et al. (2003), Li et al. (2005b) demonstrated the possibility of acquiring both parent drug quantification data and qualitative metabolite MS/MS data using the SRM-triggered information-dependent acquisition (IDA). Li et al. 14 s with the latter technique. The longer cycle time in the triple-quadrupole mode of operation would have resulted in possibly missing some of the metabolites. As shown in Fig. 27, a concentration – time profile for the parent molecule of compound A determined by the SRM-only method correlated very well with the SRM-triggered IDA method.