By Michael H. Weisman MD, John D. Reveille, Desiree van der Heijde
Constructed as a spouse textual content to the third version of the heralded Rheumatology, by way of Hochberg et al., this state of the art reference offers cutting-edge figuring out of the spondylarthropathies. you will discover thorough examinations of the leading edge, new remedies that problem older strategies of remedy and administration of the sickness. famous specialists within the box additionally current the newest innovations in early analysis utilizing complex imaging innovations * state-of-the-art wisdom of the pathogenetic and epidemiologic positive aspects * crucial new advancements in immunology * and the latest knowing of the socio-demographic effect of the disease.
- Describes cutting edge remedy and administration ideas that enable you offer sufferers with tremendous aid in soreness, morbidity, and the extra dire results of the affliction.
- allows fast connection with the disease's actual manifestations via accomplished assurance of its scientific elements.
- helps you to confirm the efficacy of organic brokers in response to the newest insights on new cures, together with anti-TNF.
- Assesses the advantages and boundaries of obtainable imaging modalities within the prognosis and administration of spondylarthropathies.
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Extra resources for Ankylosing spondylitis and the spondyloarthropathies
Singal DP, Li J, Zhang G. Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis. Clin Exp Rheumatol. 2001;19:451–452. 51. Ricci-Vitiani L, Vacca A, Potolicchio I, et al. MICA gene triplet repeat polymorphism in patients with HLA-B27 positive and negative ankylosing spondylitis from Sardinia. J Rheumatol. 2000;27:2193–2197. 52. Yabuki K, Ota M, Goto K, et al. Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis.
119 CONCLUSION Great progress has been made in elucidation of the factors involved in the pathogenesis of AS in recent years. It has become clear that HLA-B27, the primary genetic factor identified in AS pathogenesis, functions in a variety of roles including “classical” antigen presentation. How these lead to AS remains to be seen. examined, especially through international collaborations that will address the power concerns. On the other hand, less recent progress has been made in non-MHC factors.
32 in PsA, genome-wide scans in psoriasis itself have mapped a major susceptibility locus to a 60-kb interval telomeric to HLA-C in the MHC known as PSORS175 (Fig. 1). PSORS1 is closely linked to the corneodesmosin (CDSN) gene, 160-kb telomeric of HLA-C, which functions in corneocyte cohesion and desquamation and whose potential identity as PSORS1 is controversial (Fig. 1). 79 Non-Major Histocompatibility Complex Genes CYP2D6 Few candidate genes have been definitively implicated outside the MHC.