African Horse Sickness by Philip S. Mellor, Matthew Baylis, Christopher Hamblin,

By Philip S. Mellor, Matthew Baylis, Christopher Hamblin, Charles H. Calisher, Peter P.C. Mertens

African horse illness virus is a double-stranded RNA virus which motives a non-contagious, infectious arthropod-borne affliction of equines and infrequently canines. 9 particular, the world over known serotypes of the virus have to this point been pointed out. This booklet is predicated upon the findings of 2 programmes funded via the eu fee. it is going to be of price not just to the expert learn employees but in addition to veterinary staff facing regulate and to legislators looking to advertise secure overseas flow of equines. the themes coated contain cutting-edge discussions on diagnostics, vaccines, molecular biology, vector experiences, and epidemiology.

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No other pathological changes consistent with AHS were observed. The titres of infectious AHSV and viral antigen in representative tissues collected post mortem from the four donkeys euthanized sequentially after infection are given in Table 2. Table 1. 0°C was recorded from day 3 in-the two older ponies (Pi and P2). Slight oedema of the supraorbital fossae was evident in these animals from days 4 and 5, respectively, after infection. The condition of the ponies declined rapidly and by day 8 both animals had congested conjunctival and oral membranes and were dyspnoeic.

Further information on the course of infection in animals infected with more than one serotype is necessary to determine if facilitation is responsible for the associations observed. Negative associations between serotypes might be expected, considering the known cross-immunity between AHS virus serotypes. However, if serotype identification is compromised by cross-immunity (as for AHS virus), then artefactual positive associations may result. Tests with cross-reacting serotypes combined are more conservative, and will reduce this problem.

This virus was subsequently passaged on two occasions by intravenous inoculation of 11 day old embryonated hens eggs and once by subcutaneous (SC) inoculation into a pony. Spleen tissue collected post mortem from this pony was homogenised in an equal volume of Eagle's medium and lyophilised to provide the stock seed virus designated AHSV 4 H j E 2H j • The AHSV 5 was originally obtained from Dr. B. Erasmus, Onderstepoort Veterinary Institute, S. Africa as lyophilised mouse brain passage 3 (AHSV 5 MB3).

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