Adhesion Molecules: Function and Inhibition by Klaus Ley

By Klaus Ley

Inflammatory phone recruitment calls for the concerted motion of at the least 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate buildings serving as selectin ligands, and likely ectoenzymes. This quantity offers a entire evaluate at the such a lot correct leukocyte and endothelial adhesion molecules. The chapters are written through leaders within the box and concentrate on the biology, constitution, functionality, and legislation of adhesion molecules. at present authorized adhesion molecule-based treatments are reviewed and an outlook for destiny ways can be provided.

The publication is of curiosity to clinicians and scientists from immunology, body structure, melanoma examine, rheumatology, allergology, infectious ailments, gastroenterology, pulmonology and cardiology.

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Adhesion Molecules: Function and Inhibition

Inflammatory phone recruitment calls for the concerted motion of a minimum of 5 significant units of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate buildings serving as selectin ligands, and sure ectoenzymes. This quantity supplies a complete assessment at the such a lot appropriate leukocyte and endothelial adhesion molecules.

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J Biol Chem 272: 28750–28756 Celi A, Pellegrini G, Lorenzet R, De Blasi A, Ready N, Furie BC, Furie B (1994) P-selectin induces the expression of tissue factor on monocytes. Proc Natl Acad Sci USA 91: 8767–8771 Damle NK, Klussman K, Dietsch MR, Mohagheghpour N, Aruffo A (1992) GMP-140 (P-selectin/CD62) binds to chronically stimulated but not resting CD4+ T lymphocytes and regulates their production of proinflammatory cytokines. Eur J Immunol 22: 1789–1793 Haller H, Kunzendorf U, Sacherer K, Lindschau C, Walz G, Distler A, Luft FC (1997) T cell adhesion to P-selectin induces tyrosine phosphorylation of pp125 focal adhesion kinase and other substrates.

Several possibilities can be proposed to explain these effects including up-regulation of chemokine receptor expression and/or close physical proximity of L-selectin and the chemokine receptor allowing for “cross talk” to occur between these two molecules. In fact, Ding et al. [10] reported that activation through L-selectin enhanced stromal cell-derived factor-1_ (SDF-1_)-mediated adhesion and transendothelial migration of leukocytes by up-regulating the functional expression of its receptor CXCR4.

In this same study, another line of mice was created by crossing L(E) and L-selectindeficient mice, denoted L(E)SAME, that expressed near wild-type levels of L-selectin on leukocytes. Results using these mice showed that cleavage of L-selectin was not required for regulating normal neutrophil rolling interactions or for migration of lymphocytes to PLN. Similarly, studies using a transgenic line of mice that express a cleavage-resistant form of L-selectin (L6P) on T cells found these cells had equivalent rolling interactions and migration to PLN as wild-type cells [30].

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